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Furthermore, calcium overload activates calpains, calcium-dependent proteases, which degrade cytoskeletal and membrane proteins, thereby contributing to structural damage and impaired contractility [8]

TaherATOrigaRPerrottaSKourakliARuffoGBKattamisAet alNew film-coated tablet formulation of deferasirox is well tolerated in patients with thalassemia or lower-risk mds: results of the randomized, phase II eclipse study

Most of these are gene mutations, which express toxic protein products that directly damage mitochondria

Briefly, pellets containing 30 x 10 6 cells were rinsed with the provided Assay Buffer, sonicated, and centrifuged at 300 x g for 15 min at 4C