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However, information explaining the connection between homocysteine and CKD is still lacking [12]

"Your body will use what it wants and eliminate the rest." If you're interested in taking a B12 supplement, it's a good idea to talk to your doctor first because B12 supplements can interact with some medications like chloramphenicol (a type of antibiotic) and metformin (which is used to treat diabetes) or simply may not be necessary for you

It is a targeted tool for patients already close to their ideal body composition who have specific localised deposits that don't respond to exercise and diet