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Perioperative implications were evaluated with emphasis on orthopaedic surgical risk domains relevant to total joint arthroplasty (TJA), including wound complications, hematoma formation, immune modulation, infection susceptibility, heterotopic ossification, and implant fixation considerations

Antibody levels were found to be: Clinically relevant: greater than 250 IU/mL Partial responders: between 50-250 IU/mL Non responders: less than 50 IU/mL The researchers found that individuals with smouldering myeloma responded better to vaccines and only 45% of patients with active myeloma developed a clinically relevant response