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Furthermore, our preliminary experiment revealed that long-term (12 weeks) supplementation of glutathione (50 mg/kg body weight) in mice did not significantly increase liver glutathione levels compared to than in controls, indicating that oral administration of glutathione does not significantly affect the glutathione levels in the liver, when sufficient amounts of glutathione can be synthesized

27 observed reduced nitrate and antioxidant enzyme levels (SOD and catalase) in DOCA-salt rats

We further evaluated the clinical relevance of these findings by analyzing the expression of ACTL6A and GCLC with a tissue microarray containing 184 GC tissue specimens