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5d, an increase in the activity of caspase 3 and/or 7 was observed in cells on Day 4 of siRNA infection, suggesting that apoptosis was eventually induced by GSTP silencing

Among the key causative agents, anthracyclines, such as doxorubicin (DOX), are particularly notable, as the severe cardiac damage they inducecharacterized by ventricular dilatation, interstitial fibrosis, and progression to HFsignificantly limits their clinical utility [73]

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