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When the damage surpasses the cells repair capacity, apoptotic pathways are activated, involving the expression of p53 and Bcl2 Associated X Protein (BAX, part of the Bcl-2 family proteins), the cytochrome c release, and the activation of caspase-3, -7 and -9, leading to apoptosis [2,19,24,30,31]

A more comprehensive assessment of the bodys redox status can be achieved by measuring total antioxidant activity (TAA)

23 The benefits of exercise in cardiovascular health can also be related to exercise-induced physiological cardiac hypertrophy, structural and functional vascular remodeling, as well as cardiac metabolic adaptations in mitochondrial function and glucose/lipid metabolism