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The crystals can also be broken down in the body (see 7a below, re: Rasburicase, and 7b below, re: pegylated uricase)

doi: 10.1016/J.RVSC.2011.11.008 126 TriantaphyllopoulosK

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Low levels of 5-MTHF in the brain result in impaired transport of folates across the blood-brain barrier, which has been shown to result in cerebral folate deficiency (CFD)