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PNC-27 has shown it can destroy CD44+ colon cancer stem cells, which is a big deal for preventing recurrence

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Notably, the proposed binding mode is compatible with the simultaneous binding of the substrate L-Leu- p NA, in agreement with the uncompetitive IRAP inhibition determined for a representative compound

In this reaction, 5-methyltetrahydrofolic acid participates as a methyl group donor, while cobalamin is only an intermediate acceptor of the group