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Breast cancer bone metastasis cells release lactate through MCT4, inducing the upregulation of pERK1/2 and pCREB in the dorsal root ganglia (DRG) of sensory neurons, leading to bone pain through the activation of GPR81

The ecosystem harbored inside the intestine results damaged and, consequently, this increases inflammation (by bacterial components as described) and neuroinflammation, by neuroactive compounds (even from microbial metabolism) and other neuromodulatory mechanisms, as explained below

This widespread tiredness creates high demand for energy-boosting products

Hwang IS, Choi DS, Kim NH, Kim DS, Hwang BK (2014) The pepper cysteine/histidine-rich DC1 domain protein CaDC1 binds both RNA and DNA and is required for plant cell death and defense response