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Extraintestinally, CD can cause neurological and dermatological manifestations, as well as systemic effects like neurodegenerative diseases, certain lymphomas, fatigue, and headaches (Bonner et al, 2025)

Calabrese D, Giatti S, Romano S, Porretta-Serapiglia C, Bianchi R, Milanese M, et al

Nerve cells are particularly prone to ferroptosis because of their special cell membrane composition and energy requirements (63)

For example, the analysis of normal keratinocytes treated with SDS by two-dimensional electrophoresis and MALDI-TOF (or MALDI-TOF/TOF) mass spectrometry allowed identification of a number of proteins (i.e., involucrin, peroxiredoxin 1, serine protease inhibitor, small heat shock protein 27, and some others) that could be used as general markers for skin irritation (Fletcher and Basketter 2006