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Most cytokines and their receptors are expressed by neurons and glial cells throughout development, and several studies have revealed that cytokines play important roles in neurogenesis, synapse formation, and plasticity, including IL-1, IL-6, TNF-, TGF-1 and IFN 326,327,328,329,330,331 Cytokines activate several signal transduction pathways, including the Janus kinase-signal transducer and activation of transcription (JAK-STAT) and PI3K/AKT/mTOR pathways, which regulate numerous cellular responses

Diagnostic immunohistochemistry

doi: 10.2337/db21-1072 116

Reactome pathways upregulated after both 3 and 6 h MR include tRNA aminoacylation, downstream signaling of activated Fibroblast Growth Factor Receptor, carbohydrate metabolism, and regulation of lipid metabolism by peroxisome proliferator activated receptor alpha (Table 1, Fig