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Modifier subunit is enzymatically inactive but plays an important regulatory function by lowering the Km of GCL for glutamate and raising the Ki for GSH (Huang et al

Sirait B, Wiweko B, Jusuf AA, et al

Patients with vitamin B12 deficiency often report one or more of the following: Dizziness Numbness or tingling in extremities Poor balance Fatigue or weakness Swollen tongue Heart palpitations and shortness of breath Depression Memory loss or dementia However, since many of these symptoms can be attributed to other conditions, it's important to see a physician who can test your B vitamin levels and properly diagnose the deficiency

The lungs, however, are dependent on glutathione for protection from oxidative damage