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Paroxysmal Paroxysmal OD typically arises early in life generally in childhood or adolescence (141143) and individuals presenting with paroxysmal dystonia/dyskinesia above the age of 21 should broaden the differential diagnosis and clinicians should consider a FMD as a possibility

However, in advanced age, these rhythms often become dampened or desynchronized, leading to reduced circadian robustness and greater physiological variability (Figure 3)

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1) This study performed by the research team of Park et al investigated the protective effects of the tripeptide-copper complex GHK-Cu against lipopolysaccharide (LPS)-induced acute lung injury (ALI), employing both in vitro macrophage cell cultures and an in vivo mouse model