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The severity of PEM varies widely, with recovery times ranging from hours to weeks, and it has been shown that in CFS patients who have symptoms of PEM, a physical exercise programme may lead to the worsening of their symptoms (Vink and Vink-Niese, 2020)

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Plant growth-promoting bacteria (PGPB) are among the best technologies for assisting plants in withstanding challenging environmental conditions and enhancing plant growth through a number of processes, such as mineral uptake, phosphate solubilization, nitrogen fixation, phytohormone synthesis, and the generation of various volatile compounds (Ullah et al

Specifically, resveratrol significantly increased PKA, phosphorylated cAMP-response element binding protein (p-CREB), and BDNF expression in the hippocampus of IBS rats while decreasing PKA, p-CREB, and BDNF levels in the ileum and colon [212]