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In vivo and ex vivo imaging studies indicated that A2-APM quickly detected the low-density lipoprotein receptor-related protein 1 (LRP1) on endothelial cells and GBM cells after intravenous treatment, to boost aPD-L1 and PTX entry into the tumor environment of GBM, resulting in substantially increased accumulation of antibodies in the brain in several tumor xenograft models, compared to free aPD-L1 group

Holekamp NM, Shui YB, Beebe DC

Over time, this can lead to a decline in thyroid function and the development of hypothyroidism symptoms

Toca 511 (vocimagene amiretrorepvec), a RRV which delivered a yeast cytosine deaminase suicide gene to GBM cells, has failed to demonstrate an overall survival benefit in a Phase III clinical trial, although the platform was safe [39]