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The importance of the baicalein compound (5 or 10 mg/kg) is that it prevents the accumulation of ROS molecules, reduces apoptosis, maintains ATP level, and improves mitochondrial membranes in brain cells when exposed to rotenone, which causes neurotoxicity [126]

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Recent studies on phase 1 clinical trials using, Elamipretide, a mitochondrial-targeted drug, have shown a positive effect on visual function without adverse effects (Mettu et al., 2022)

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