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In a non-cancer context, it is known that hypoxia links erythropoiesis with iron homeostasis and that the hepcidin/FPN1 axis regulates intestinal HIF2 to modulate iron absorption, through transcriptional activation of DMT1 , DCYTB , and FPN1 [118,119,120]

Based on studies carried out on murine models, the authors hypothesised that the milk pro-oxidant galactose (component of lactose) may be one of the main causes of these observed effects ( Reference Cui, Zuo and Zhang 116 Reference Hao, Huang and Gao 118 ) , with the increase in oxidative stress specifically associated with a lower life expectancy in animals ( Reference Cui, Wang and Zuo 119 ) and with chronic diseases in humans ( Reference Utkualp and Ozdemir 120 , Reference Moylan and Reid 121 )

Sci Rep 16 , 11418 (2026)

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