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Interestingly, both ATG12 and ATG5 promote apoptosis and exert anticancer effects independent of each other

However, there are key differences in the biology of T reg cells and effector T cells, including their responses to TCR stimulation 95 , co-receptor ligation 96 and cytokines 97 , that question how applicable the axioms established from the use of effector CAR T cells in patients with cancer will be to CAR T reg cells

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