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Use of inhibitors like (-) borneol (inhibit acyl glucuronidation) and tri-methylacetic acid (TMA) (inhibit Acyl CoAs formation) in a mechanistic study of 2-Phenylpropionic acid (2-PPA) showed 49% reduction in covalent binding by inhibiting thioesters compared to just 23% of reduction by glucuronidation inhibition

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Consequently, polymeric coatings have emerged as an effective solution to mitigate fouling effects by serving as antifouling coatings that render the drug carriers more biocompatible and enhance their performance for both diagnostic and therapeutic applications 10

(Princeton, NJ, USA) using a validated liquid chromatography electrospray ionisation with tandem mass spectrometric detection method over the concentration ranges of 102000 and 1000200 000 ng ml 1 (Latz et al, 2006)