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Many aggregation-prone peptides will go into solution in an organic solvent but not directly in water4

Cuprizone administration induces mitochondrial enlargement, severely alters metabolic rates, and impairs oxidative phosphorylation by reducing mitochondrial enzymes that contain copper as a cofactor, such as monoamine oxidase [27] and cytochrome c (Cyt c) oxidase [28, 29] in the brain of mice