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Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis

1 Pulmonary vasoconstriction, pulmonary vascular remodeling (PVR), and in situ thrombosis formation are the main pathological changes in PH, and they are primarily associated with impaired pulmonary vascular endothelial function caused by an imbalance between vasodilators and vasoconstrictors (nitric oxide [NO]/endothelin-1 [ET-1]), 11 abnormal PASMC proliferation, local inflammation accumulation, immune dysregulation, mitochondrial dysfunction, and metabolic reprogramming, among other factors

More specifically, the rationale for the development of this scale was based on the premise that distractive smartphone use appears to be driven primarily by the cognitive preoccupation with social media content in order to attend to needs for validation and control (of content, self-presentation, and relationships)

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