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H., Teixeira, F., Park, G

20,21 This inflammatory process driven by cytokines such as interleukin-6 (IL-6) and tumor necrosis factoralpha disrupts neuronal communication, impairing synaptic plasticity and neurotransmission

In a normal response, exposure to irritants, pathogens, or environmental toxins triggers the activation of TLRs subsequently activating your mast cells and starting the inflammatory process