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TrkB activation is among the fastest receptor-mediated signaling events in the nervous system, and deactivation occurs within roughly 30 minutes in spinal cord neurons

N.Y Acad

This hypothesis is centered on the idea that the accumulation of A peptides derived from amyloid precursor protein (APP) plays a major role in disease development

From these findings, the authors suggested that the formulation may be an attractive approach for nose-to-brain delivery of donepezil, providing advances in the AD treatment