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if this happens during transcription, the presence of oxidized mRNA chain will cause transcription errors, coupled with subsequent translational errors

Currently, there are some hypotheses supporting that patients with BD may have an altered histaminergic system, with upregulated histamine levels in manic phases and downregulated in depression, being their fluctuations closely related to other pathophysiological mechanisms [183]

Whether phase separation, which is involved in neuronal synaptic signalling, plays an important role in the pathology of SAE deserves further exploration

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