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First, feedback inhibition of GSH1 activity by GSH has often been considered a fundamental control over GSH synthesis

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Among proteins rhythmic in at least 1 genotype, a surprisingly high number (32.8%) gained rhythmicity in the kidneys of cKOt mice, while only 24.3% proteins lost their rhythmicity, 8.2% had altered rhythmicity, and 34.7% showed unaltered rhythm (Figure 1G)