Nature 618 , 144150 (2023)
Higher Risk Profile: There's a greater risk of hitting a nerve, causing a hematoma, or simply missing the optimal target zone, which could render the application less effective
129,130 These proteins are typically expressed during embryogenesis but become re-expressed in cancers while remaining largely silent in adult tissues, making them ideal targets for TCR-based and peptide-based immunotherapies, 129,131,132 Cryptic and noncanonical antigens constitute a class of tumor-associated peptides that arise from nontraditional genomic and transcriptomic regions, 133,134,135,136 Recent immunopeptidomic and translatome profiling studies have confirmed that cryptic peptides are endogenously processed and presented on MHC class I molecules across a variety of malignancies, including glioblastoma, melanoma, acute myeloid leukemia (AML), and pancreatic ductal adenocarcinoma (PDAC)
For adult multi-dose reconstitution protocols, bacteriostatic water is generally appropriate