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Liver fat reduction: By promoting hepatic fat metabolism, it shows promise in improving MASH (metabolic dysfunction-associated steatohepatitis) and reducing liver fibrosis

Figure 11 The phosphinic group is, as compared to, e.g., thiols and hydroxamic acids more weakly binding to zinc ions in metalloproteases and a significantly improved selectivity could be achieved by systematic variations of the side chains at P1 and P2 positions of 43

Added compounds can influence the overall stability profile of the formulation

For the therapy to achieve broader clinical acceptance, the establishment of standardized guidelines is paramount