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208 The local release of Cu ions around rat carotid arteries has been shown to promote the thickening of the neointima and the generation of arteriosclerotic lesions in response to vascular injury, 209 whereas the use of Cu chelators exhibit inhibitory effects on vascular inflammation, the development of atherosclerotic lesions, and neointimal formation in response to vascular injury in ApoE knockout mice

Similar content being viewed by others Introduction Colorectal cancer (CRC) is the second leading cause of cancer-related mortality, and the incidence of early-onset colon cancer has been increasing worldwide globally in recent years 1

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