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Statistical analysis Data are reported as mean values and standard deviations, and groups were compared by ANOVA followed by the Tukey post test

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FIGURE 1 Retinal eicosanoid pathways As dietary lipids supply the substrates for eicosanoid biosynthesis, observational data linking higher PUFA and lower saturated fat intake to less DR in well-controlled diabetes align with a model in which precursor pools influence pro- and anti-inflammatory lipid mediators ( COX pathway Cyclooxygenase-2 (COX-2) is upregulated in the diabetic retina, increasing conversion of arachidonic acid into bioactive prostanoids that regulate vascular permeability and inflammation