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One source of interference is the uncontrollable nature of nanoparticle aggregation and self-aggregation in complex samples, leading to high background signals and false-positive results

For example, reduced hippocampal BDNF expressiona hallmark of ethanols neurotoxicity in rodentshas been corroborated in humans, with chronic drinkers showing 50% lower BDNF levels compared to controls

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The extent to which GSH-derived amino acids are essential to cancers is unclear