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An improved understanding of genetic forms of disease has more recently facilitated the identification of amenable targets for novel gene therapies in subsets of patients with ALS

Mitophagy is mainly mediated by BCL2/adenovirus E1B 19kDa interacting protein 3/Nip3-like protein X, and Parkin/PINK1 (PTEN induced putative kinase 1) ( 2.2 Immunogenic cell death Immunogenic cell death (ICD), known as immunogenic apoptotic cell death or immunogenic apoptosis, has been defined as a form of regulated cell death that is sufficient to activate an adaptive immune response in immunocompetent hosts ( IR-induced OS can induce immunogenic death of tumor cells through multiple mechanisms ( + T cells and elicited antitumor immunity ( 2.3 Ferroptosis Ferroptosis is another way of radiation-induced tumor cell death, which is caused by lipid peroxidation caused by iron metabolism disorder and ROS accumulation