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In control rats with simultaneous occlusion of the superior mesenteric vein and artery, the tissue damage increased from the stomach to the large bowel, with marked transmural congestion within the stomach, duodenum, intestine, and rectum (Figure 11)

Mechanistically, UA induces programmed cell death (apoptosis) and triggers cell cycle arrest at the G0/G1 phase through downregulation of the Wnt/-catenin signaling cascade (Zhao et al., 2023)

Key Benefits: - Promotes a more even skin tone - Reduces the appearance of dark spots and hyperpigmentation - Helps to brighten and illuminate the skin - Supports overall skin health and radiance How It Works: Alpha Arbutin and Kojic Acid Dipalmitate are known for their skin brightening properties, helping to inhibit melanin production and reduce the appearance of dark spots

Similarly, it was proved from Atamna's research that reduced glutathione (GSH) can degrade heme in solution with a pH of 7 [11]