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Additionally, homotaurine reduced the increase in oxidative stress biomarkers and inflammatory cytokines, such as IL-1, IL-6, and TNF- levels, caused by VPA in rats, decreased pyknosis in the prefrontal cortex, and restored the size and number of Purkinje cells in the cerebellum and regulated the dysregulated expression of GAD67 due to VPA exposure (158)

In terms of transcriptional regulation, the decrease of glutathione leads to a decrease in the transcriptional repressor ArgR (EF0983, regulator of arginine metabolism) (25, 26), and an increase in the expression levels of global transcription factors belonging to the LysR families (EF0644, EF0923 and EF2958) and TetR (EF0791, EF0787, EF2203, EF2066), which are involved in basal metabolism, energy generation and general stress responses, therefore suggesting that glutathione depletion induces regulatory adjustments at the transcriptional level which could lead to important changes in the basal metabolism of E

Changes in the gut microbiome associated with infliximab in patients with bipolar disorder

Patients with refractory Crohn's disease or ulcerative colitis respond to dehydroepiandrosterone: a pilot study