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Inhibition of phosphodiesterase: A novel therapeutic target for the treatment of mild cognitive impairment and Alzheimers disease

As melatonin levels decrease, the impact on cyclic nucleotide signalling could lead to several age-related health problems, underscoring melatonins role in preserving physiological equilibrium throughout ones life

The NPs were loaded with a CRISPR activation system plasmid designed to activate the Nrf2 gene, therefore promoting the expression of antioxidant proteins and restoring redox homeostasis (Figure 8A)