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Drug Discov Today

Research Background DSIP has been investigated in preclinical models for its proposed neuromodulatory roles, including effects on sleep architecture, stress response, and the hypothalamic-pituitary axis

10.1007/s10787-006-1531-7 72 SikiricP.SeiwerthS.BrcicL.SeverM.KlicekR.RadicB.et al (2010)

Adding semaglutide to retatrutide would duplicate GLP-1 receptor activation, which could increase side effects without proportionally increasing efficacy