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98 Caffeine is an adenosine receptor antagonist, and epidemiological studies have shown that the intake of caffeine is closely related to the occurrence of suicide 99 and depression

Deoxycholic acid (D2510), cycloheximide (C7698), dipicolinic acid (P63808), Lipopolysaccharides from Escherichia coli O111: B4 (L2630), concanavalin A (C2010) were purchased from Sigma-Aldrich (St

doi: 10.1186/s13063-018-3076-7 62 RechJTascilarKHagenMKleyerAMangerBSchoenauVet al

In wildtype mice, optogenetic inhibition of GABAergic interneurons in the medial prefrontal cortex (mPFC) leads to cognitive deficits ( +/ ) or absent (PV / ) expression exhibit the core ASD-like symptoms ( In addition, Reelin is an extracellular matrix glycoprotein closely related to neural development, which is involved in the regulation of neuronal migration, synaptic plasticity and neural network formation ( 3.2 The relationship between GABAergic signaling pathway abnormalities and ASD 3.2.1 The synthesis, release, transport, and metabolism of GABA The biosynthesis of GABA primarily relies on the decarboxylation of glutamate catalyzed by GAD