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Moreover, the present findings of MeCbl, an endogenous coenzyme form of vitamin 12, engaging with GSDME-mediated pyroptosis, together with other exciting findings about the signaling metabolites involved in diverse cell death signals, may pave a way in innovating metabolic bionics guided drug discovery against cell death signals, for which the endogenous signaling metabolites can serve as leading compounds for drug design 48

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Dumbrava EEI, Pinchasik D, Damodar S, Hess K, Pairawan SS, Moore J Hong DS, Janku F, Rodon J, Piha-Paul SA, Murthy R, Tapia C, Litton J, Luna K, Stuckett AS, Ferari D, Andreeff M , Tripathy D, Aivado M, Meric-Bernstam F