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Following generation of the EH 2 a second NADPH binds and donates electrons generating the EH 4 form, which is competent for substrate reduction

Currently, most studies primarily focus on the changes in ROS, which oversimplifies the underlying mechanisms of nanozyme catalysis in chronic wound healing [238,239,240]

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Consequently the strong reactivity of ozone, which has an electrochemical potential value, E = +2.076V, has contributed to establish the dogma that ozone is always toxic and its medical application must be proscribed