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SCFAs further alleviate cutaneous photoaging by activating G protein-coupled receptors (GPCRs), downregulating pro-inflammatory cytokines (e.g., IL-1, IL-6), and inhibiting MMP-1/MMP-3 expression, thereby reducing collagen degradation (Peterson et al., 2019)

NK cell percentages were lower in the group with high metabolite levels than in the group with low metabolite levels ( P = 0.04)

Increased expression or activity of NADPH oxidase was reported in coronary and peripheral arteries of patients with coronary artery disease [72,73,74]

Citicoline and its associated choline-containing components have been suggested to counter the effects of insulin resistance (Gao et al., 2017)