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[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Williams RS & Nikitin D The internet market for kratom, an opioid alternative and variably legal recreational drug

It has a favorable safety profile, with most studies documenting minimal side effect rates, with tolerance comparable to placebo

Standard Dosing Parameters Primary Application Dosing 1-2 mg daily 2-3 mg daily or 2 mg 2-3x per week 1-2 mg daily (injectable or topical) 2-5 mg daily under medical supervision Clinical studies used 0.3 mg/mL injections, while systemic wound healing in animal studies used approximately 1.1 mg/kg body weight (translating to ~75 mg total for humans in divided doses)