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[16] [81] [82] GHB tends to cause rapid unconsciousness at doses above 3500 mg, with single doses over 7000 mg often causing life-threatening respiratory depression, and higher doses still inducing bradycardia and cardiac arrest

The World Health Organization (WHO) recommends that all people 50 and older who live in a country where shingles is a concern, such as the United States, get the shingles vaccine, even if they: Had shingles in the past (its possible to get shingles more than once) Received the old live zoster vaccine (Zostavax), which the recombinant zoster vaccine (Shingrix) replaced The WHO also recommends that adults (18 and older) get the shingles vaccine if they have a weakened immune system either from a condition like cancer or HIV or from certain medications that make them more vulnerable to shingles

Course length should be decided by clinical indication rather than cost

doi: 10.1371/journal.pone.0187033