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Excessive -synuclein aggregation in PD further exacerbates autophagy dysfunction while contributing to neuroinflammation

Ledo et al., 2016), in agreement with the existence of common pathological features between AD and major depressive disorder (Torrisi et al., 2019)

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In particular, lysosomal cholesterol accumulation may predispose to APAP hepatotoxicity by a dual mechanism involving the impairment of mitophagy in hepatocytes and the disruption of TLR9 trafficking in LSEC