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As the disease progresses, reduced cerebral glucose metabolism is caused by a variety of factors, including decreased neuronal glucose uptake, impaired aerobic glycolysis and the tricarboxylic acid cycle, disrupted axonal transport function, and glial cell failure to supply energy to neurons

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If concomitant use of CYP3A4 inhibitor is necessary, consider dosage reduction of acetaminophen and codeine phosphate tablets until stable drug effects are achieved