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* Correspondence: Toluwalase Awoyemi [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Synthesis of the thio-ether substrate (8) Thio-ether 8 was prepared following a literature procedure 39

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Administration of a specific interleukin-1 receptor antagonist (IL-1ra) can block the inhibition of peptide chain initiation and the downregulation of eIF-2B expression during sepsis, thus reducing sepsis-induced suppression of protein synthesis [130]