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Further mutants are obviously necessary to decipher the exact role of Tyr110 and to precisely map the glutathione interaction sites in future studies

Specifically, polymorphisms in the Na V 1.4 (SCN4A-rs2302237) and Na V 1.8 genes (SCN10A-rs1263292) have been associated with increased incidence of acute oxaliplatin-induced neuropathy (Argyriou et al., 2013a), while patients carrying a polymorphism (rs6746030) in the SCN9A gene encoding for Na V 1.7 seem to develop less severe neuropathy than patients carrying other SCN9A gene variants (Sereno et al., 2017)

Additional information Sources & References INT J MOL SCI Regenerative & Protective Actions of GHK-Cu 2018 Pickart L, Margolina A