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Peptides are different from bigger proteins and classical hormones mostly in size and pharmacology

Lipid peroxidation, DNA damage, and protein oxidation within spermatozoa result from OS, which occurs due to an imbalance between endogenous antioxidant defenses and reactive oxygen species (ROS) generation [2, 3]

Tryptase and urinary mast cell mediators will be highlighted in this review as they are currently the most clinically available and studied biomarkers of mast cell activation

Sibutramine has only little clinical relevance as an antidepressant but enhances weight loss due to an increase in energy expenditure and inhibition of food intake (37)