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Neuropsychopharmacology 28(5):939946 Mikhalitskaya EV, Vyalova NM, Bokhan NA, Ivanova SA (2024) Alcohol-induced activation of chemokine system and neuroinflammation development

23 These methylation marks are preserved for the rest of the life of an organism, with small tissue-specific changes.23 Of note, recent studies suggest that rearrangement of DNMT protein domains influences their enzymatic activity, which may contribute to the development of disease (both autoimmune and non-autoimmune).2427 Methylation patterns of the germline and somatic cell lineages are established during early embryonic development