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The animals are heterozygote carriers of a mutation in the insulin 2 gene

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Excess copper enters via CTR1, and excess ROS reduces GSH and drives OX-LDL production, contributing to atherosclerosis, Drp1-mediated fission, mPTP opening, and ultimately cuproptosis

Larger, more complex peptides or those with specific modifications often have built-in resistance to this degradation, giving them a much longer half life