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All PK and in vivo experiments were conducted in accordance with the animal welfare procedures and were approved by the UTMDACC IACUC

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PRLM treatment also decreases the secretion of inflammatory cytokines, including TNF-, IL-1, and IL-6, and prevents tissue injury by inhibiting inducible nitric oxide synthase, COX-2, and myeloperoxidase activation [270,271,272]