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Its mechanism involves stimulating natural GH release specifically to reduce visceral adipose tissue, with research originally focused on HIV-associated lipodystrophy

Photochemical & Photobiological Sciences: Official Journal of the European Photochemistry Association and the European Society for Photobiology

The reason: since the fragment contains only the C-terminal part, it lacks the binding domains for GHR (most of the affinity of hGH for GHR lies in the central part of the molecule)

LDEs also feed forward to alkylate and alter the activity of membrane channels, such as MRP1, TRP channels, Piezo1, and the Na + /K + -ATPase ( Step 4 ), leading to calcium influx and loss of the cation gradient ( Step 5 ) (32)